TLS Online TPP Program

#Question id: 1035


A new drug is developed that inhibits formation of the flagellar filament by impairing production of the protein flagellin. Is this going to be a good drug?

#Unit 4. Cell Communication and Cell Signaling
  1. Potentially-it would definitely only impair bacteria, but wouldn't matter for the ones that don't use a flagellum to move around.

  2. Potentially-if it could be shown that it also didn't impair the production of the eukaryotic flagellum.

  3. No-our eukaryotic cells depend on flagella to move around in our body, and this would impair that function.

  4. No-bacterial flagella are produced using microtubules, not the protein flagellin. This drug would be useless in eliminating bacteria.

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TLS Online TPP Program

#Question id: 33476

#Unit 2. Cellular Organization

Find true and false statements
A. The structures of eukaryotic genes show extensive variation. 
B. Some eukaryotic genes are uninterrupted and their sequences are colinear with those of the corresponding mRNAs. 
C. Most multicellular eukaryotic genes are interrupted, but the introns vary enormously in both number and size.

TLS Online TPP Program

#Question id: 33477

#Unit 2. Cellular Organization

Finding: Ancestry have similar organizations with conservation of the positions (of at least some) of the introns.

Example: The globin and DHFR genes are examples of a genes that share a common ancestor

TLS Online TPP Program

#Question id: 33478

#Unit 2. Cellular Organization

Find true and false statements
A. Comparisons of related genes in different species show that the sequences of the corresponding exons are usually conserved
B. when two genes are related, the relationship between their exons is closer than the relationship between their introns.
C. The sequences of the introns are much less similar.
D. Introns evolve much more rapidly than exons because of the lack of selective pressure to produce a polypeptide with a useful sequence.

TLS Online TPP Program

#Question id: 33479

#Unit 2. Cellular Organization


TLS Online TPP Program

#Question id: 33480

#Unit 2. Cellular Organization

Finding: The overall degree of divergence between two homologous exons in related genes corresponds to the differences between the polypeptides.

Reason: Overall degree of divergence between two homologous exons is mostly a result of base substitutions.

TLS Online TPP Program

#Question id: 33481

#Unit 2. Cellular Organization

A. In homologous introns, the pattern of divergence involves both changes in length.
B. Divergence in introns is due to deletions and insertions and base substitutions. 
C. Introns are slowly evolve while exons much more rapidly 
D. When a gene is compared among different species, there are instances where its exons are homologous but its introns have diverged so much that very little homology is retained.