Following statements are regarding to the wnt signalling.

A. Wnt proteins interact with several cell-surface proteins and activate multiple downstream signal transduction pathways. The principal signaling receptor for Wnt proteins is Frizzled (Fz), which contains seven transmembrane α helices.

B. The palmitate attached to the Wnt protein binds to a specific site on the Fz intracellular domain and stabilizes the Wnt-Fz complex.

C. “canonical” Wnt signaling pathway uses a second transmembrane protein, LRP, that associates with Frizzled in a Wnt signal– dependent manner.

D. In the resting state, two kinases in the complex, casein kinase 1 (CK1) and GSK3, sequentially phosphorylate β-catenin on multiple tyrosine residues.

Which of the following statements are correct?

#Question id: 4511

#Unit 3. Fundamental Processes

The proteins are not needed for the splicing reaction itself, because

#Question id: 4512

#Unit 3. Fundamental Processes

Some pre-mRNAs can be spliced in more than one way. Thus, mRNAs containing different selections of exons can be generated from a given pre-mRNA, called

#Question id: 4513

#Unit 3. Fundamental Processes

Different snRNPs recognize the same (or overlapping) sequences in the pre-mRNA at different stages of the splicing reaction, which two snRNPs recognizing the 5’ splice site

#Question id: 4514

#Unit 3. Fundamental Processes

What is true about coactivators,

A. The coactivators act directly by binding to the DNA

B. The coactivators act indirectly—not by binding to the DNA

C. Are required for essential communication between the activators and the complex composed of Pol II.

D. Are required for essential communication between the and the basal (or general) transcription factors.

#Question id: 4515

#Unit 3. Fundamental Processes

Transcription Activators are,

A. Known to facilitate transcription at hundreds of promoters,

B. Specific for a few promoters,

C. Sensitive to the binding of signal molecules,

D. Providing the capacity to activate or deactivate transcription in response to a changing cellular environment.

#Question id: 4516

#Unit 3. Fundamental Processes

High mobility group (HMG) proteins

A. are a common type of architectural regulator

B. facilitating the looping of the DNA

C. the binding is relatively very specific

D. are abundant in chromatin and bind to DNA with limited specificity.