Following statements are regarding to the desensitization mechanism of GPCR.

A. Several residues in the cytosolic domain of the β-adrenergic receptor are phosphorylated by the enzyme rhodopsin kinase.

B. β-Arrestin binds to specific phosphorylated tyrosine residues in the C-terminal segment of G protein–coupled receptors (GPCRs).

C. Clathrin and AP2, two other proteins bound by β-arrestin, promote endocytosis of the receptor.

D. β-Arrestin also functions in transducing signals from activated receptors by binding to and activating several cytosolic protein kinases like Src activates the MAP kinase pathway, leading to phosphorylation of key transcription factor.

Which of the following combination is incorrect?

#Question id: 4876

#Unit 8. Inheritance Biology

A panel of cell lines was created from mouse–human somatic cell fusions. Each line was examined for the presence of human chromosomes and for the production of human haptoglobin (a protein). The following results were obtained: On the basis of these results, which human chromosome carries the gene for haptoglobin?

#Question id: 4877

#Unit 8. Inheritance Biology

In rabbit, spotted pattern is dominant over solid colour and short hair over angora . A F1 spotted short hair was test cross to solid colour angora stock. The cross produced

Spotted angora               - 26                        

Solid coloured angora     144

Spotted short hair            157                      

Solid colour short hair       23

What is the recombination percentage between  genes?

#Question id: 4878

#Unit 8. Inheritance Biology

Two strain of Neurospora crassa , one mutant for gene a , other mutant for gene b , are crossed ,result are shown below

A and B gene located at

#Question id: 4879

#Unit 8. Inheritance Biology

A wild plant with genes AABBCC was crossed with a triple recessive mutant aabbcc. The F1 male hybrid (AaBbCc) was then back crossed with the triple mutant and the phenotypes recorded are as follows

AabbCc (50), aaBbcc(50), AaBbCc (100), aabbcc (100), AaBbcc (350), aabbCc (350)

Distance between A to B is ----------M----- map unit with ………N…….configuration, distance between B to C is ----O---- map unit with ------P-------configuration?

#Question id: 4880

#Unit 8. Inheritance Biology

There is following normal gene and their restriction site are given

 Mutant phenotype due to mutation that alters EcoRI site 1 occurs in this piece of DNA. There is following analysis of different band in their family (+ present , - absent) 

 Which of the following is mode of inheritance of trait?

#Question id: 4881

#Unit 8. Inheritance Biology

A panel of cell lines was created from mouse–human somatic-cell fusions. Each line was examined for the presence of human chromosomes and for the production of three enzymes. The following results were obtained On the basis of above results. Which of the following chromosome location of enzyme 1, enzyme 2, and enzyme 3?