Following statements are regarding to the desensitization mechanism of GPCR.

A. Several residues in the cytosolic domain of the β-adrenergic receptor are phosphorylated by the enzyme rhodopsin kinase.

B. β-Arrestin binds to specific phosphorylated tyrosine residues in the C-terminal segment of G protein–coupled receptors (GPCRs).

C. Clathrin and AP2, two other proteins bound by β-arrestin, promote endocytosis of the receptor.

D. β-Arrestin also functions in transducing signals from activated receptors by binding to and activating several cytosolic protein kinases like Src activates the MAP kinase pathway, leading to phosphorylation of key transcription factor.

Which of the following combination is incorrect?

TLS Online TPP Program

#Question id: 14981

#Unit 2. Cellular Organization

The endoplasmic reticulum has many important functions. It transports proteins, lipids, and probably other materials through the cell. The ER is also a major site of 

TLS Online TPP Program

#Question id: 14982

#Unit 2. Cellular Organization

A very important function of the Golgi apparatus and endoplasmic reticulum is the synthesis of another organelle, the lysosome. This organelle is found in a variety of organisms such as—

1.Protozoa 

2. Some algae

3. Fungi

4. Plants 

5. Animals

In which of the above organisms lysosome is not found.

TLS Online TPP Program

#Question id: 14983

#Unit 2. Cellular Organization

A network of intermediate filaments, called the nuclear lamina, lies against the inner surface of the envelope and supports it. Which structure usually is associated with the inner membrane

TLS Online TPP Program

#Question id: 14984

#Unit 2. Cellular Organization

Just beneath the plasma membrane  many protozoa and some algae have a different external, rigid layer of components. The structure is called as

TLS Online TPP Program

#Question id: 14985

#Unit 4. Cell Communication and Cell Signaling

Neutrophills containing granules which have protease, protease inhibitors, for example

a) α-1 antitrypsin – regulation of proteases

b) Defensin – Direct harm to pathogen

c) Elastase –  Tissue remodelling

d) MBP – basophil degranulation

TLS Online TPP Program

#Question id: 14986

#Unit 4. Cell Communication and Cell Signaling

Which of the following characteristics of granulocyte is correct?