Following statements are regarding to the phosphoinositide pathway.

A. many activated RTKs and cytokine receptors initiate phosphoinositide pathway by recruiting the enzyme phosphatidylinositol-3 kinase (PI-3 kinase) to the membrane.

B. PI-3 kinase adds a phosphate to the 3′ carbon in one of two separate phosphatidylinositol substrates, leading to formation of two phosphatidylinositol 3-phosphates: PI(3,4)P2 or I(3,4,5)P3

C. PI-3 kinase pathway can trigger cell division and prevent apoptosis, thus ensuring cell survival by the activation of PKB.

D. Activated PKB phosphorylates FOXO3a, which induces the expression of several antiapoptotic genes.

Which of the following combination is correct?

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#Question id: 33900

#Unit 2. Cellular Organization

A. Bacterial genome have many independent chromosomal domains

B. Bacterial genome is circular and have many intertangled domains 

C. Each domain consists of 40 kilobases (k2. of DNA 

D. The existence of separate domains donot permit different degrees of supercoiling to be maintained in different regions of the genome.

Find true and false

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#Question id: 33904

#Unit 2. Cellular Organization

A. The bacterial nucleoid is 80% DNA by mass.

B. Bacteria have similar morphological features as of eukaryotic chromosomes, 

C. Bacterial genomes are organized into definite substructures within the cell. 

D. Bacterial Protein HU is a dimer that condenses DNA, possibly wrapping it into a beadlike structure.

Find true and false

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#Question id: 33905

#Unit 2. Cellular Organization

E. coli DNA in vivo corresponds to an average density of 1 negative superhelical turn/200 bp it means it has 

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#Question id: 33906

#Unit 2. Cellular Organization

Which is correct combination of statements

A. Bacterial genome has independent sets of domains and each domain consists of a loop of DNA.

B. Presence of domain in genome can be analyzed by EtBR intercalation and DNase treatment 

C. Early data suggested that each domain consists of 10kb-40 kb of DNA

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#Question id: 33907

#Unit 2. Cellular Organization

A circular DNA molecule with 580,070 bp. Calculate the molecular weight and contour length (when relaxed) of this molecule. What is Lko for the Mycoplasma chromosome? If σ=-  0.06, what is Lk?

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#Question id: 33908

#Unit 2. Cellular Organization

How is the linking number altered if one DNA strand is broken