Following statements are regarding to the phosphoinositide pathway.

A. many activated RTKs and cytokine receptors initiate phosphoinositide pathway by recruiting the enzyme phosphatidylinositol-3 kinase (PI-3 kinase) to the membrane.

B. PI-3 kinase adds a phosphate to the 3′ carbon in one of two separate phosphatidylinositol substrates, leading to formation of two phosphatidylinositol 3-phosphates: PI(3,4)P2 or I(3,4,5)P3

C. PI-3 kinase pathway can trigger cell division and prevent apoptosis, thus ensuring cell survival by the activation of PKB.

D. Activated PKB phosphorylates FOXO3a, which induces the expression of several antiapoptotic genes.

Which of the following combination is correct?

#Question id: 2990

#Unit 2. Cellular Organization

Mitotic CDK complexes are maintained in an inactive state through inhibitory phosphorylation of the CDK subunit. Two highly conserved tyrosine and threonine residues in mammalian CDKs are subject to regulated phosphorylation.

The following table enlists genes and phenotypes observed on mutation of these genes but not correctly matched. Which one of the following combinations is correctly matched ?

#Question id: 2991

#Unit 2. Cellular Organization

Early observations of a cultured cell line indicated that the cells did not exhibit either density-dependent inhibition or anchorage dependence. What do these observations suggest about this cell line?

#Question id: 2992

#Unit 2. Cellular Organization

DNA was isolated from three different cell types of the same organism, the relative DNA content for each type was determined, and the results were plotted on the graph shown in the figure below. Refer to the graph to answer the following questions. Which sample of DNA might be from a cell that stopped the process of cell division in G0 phase of the cell cycle prior to meiosis?

#Question id: 2993

#Unit 2. Cellular Organization

During meiosis, a defect occurs in a cell that results in the failure of spindle microtubules binding at the kinetochores. Which of the following statements describes the most likely result of such a defect?

#Question id: 2994

#Unit 2. Cellular Organization

If a cell has completed meiosis I and the first cytokinesis, and is just beginning meiosis II, which of the following is an appropriate description of its genetic contents?

#Question id: 2995

#Unit 2. Cellular Organization

 Which of the following incorrect pair?