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TLS Online TPP Program

#Question id: 1262

Although MAP kinase is often activated in multicellular animals by RTKs or cytokine receptors, signaling from other receptors can activate MAP kinase in other eukaryotic cells. we consider the mating pathway in the yeast S. cerevisiae, a well-studied example of a MAP kinase cascade linked to G protein–coupled receptors (GPCRs). Which of the following statement is incorrect?

#Unit 4. Cell Communication and Cell Signaling

  1. An a haploid cell secretes the a mating factor and has GPCRs for the α factor on its cell surface; an α cell secretes the α factor and has GPCRs for the a factor. Thus each type of cell recognizes the mating factor produced by the opposite type.

  2. Ligand binding and dissociation of the G protein subunits, the membrane-tethered Gβγ subunit binds the Ste5 scaffold to the plasma membrane.

  3. Gβγ also activates Cdc24, a GAP for the Ras-like protein Cdc42; the active, GTP-bound Cdc42, in turn, binds to and activates the Ste20 kinase.

  4. Ste20 then phosphorylates and activates Ste11, which is analogous to Raf and other mammalian MEK kinase (MEKK) proteins. Ste20 thus serves as a MAPKKK kinase.

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TLS Online TPP Program

#Question id: 3361

#Unit 11. Evolution and Behavior

In a population 16% individual affected with autosomal recessive diseased. how many are expected to be normal phenotype if population size is 250 ?
TLS Online TPP Program

#Question id: 3362

#Unit 11. Evolution and Behavior

The Hardy-Wienberg principle comes from considering what happens when Medelian genes act on population. The model predicts that there will be no change in allele frequencies when
TLS Online TPP Program

#Question id: 3363

#Unit 11. Evolution and Behavior

An autosomal recessive condition affects 1 newborn in 100 in a random mating population without any disruptive acting force. What is the approximate expected frequency of carriers in this population?
TLS Online TPP Program

#Question id: 3364

#Unit 11. Evolution and Behavior

Which of the following equations represents the corresponding equilibrium for a locus with three alleles p, q and r of diploid individuals? (P, Q and R represent the frequencies of p, q and r, respectively)
TLS Online TPP Program

#Question id: 3365

#Unit 11. Evolution and Behavior

Consider a population of 10,000 individuals, of which 2500 are homozygotes (PP) and 3000 are heterozygotes (Pp) genotype. The frequency of allele p in the population is
TLS Online TPP Program

#Question id: 3366

#Unit 11. Evolution and Behavior

Red-Green color blindness is an X-linked recessive disorder. In a population which is in the Hardy-  Weinberg equilibrium, the incidence of occurrence of this in males is 2:2000. What will be the expected incidence of affected homozygous females?