This member of the AKAP family, designated mAKAP, anchors both PDE and the regulatory subunit  of PKA to the nuclear membrane, maintaining them in a negative feedback loop that provides close local control of the ATP level and PKA activity.

B- The basal level of PDE activity in the presence of hormone (resting state) keeps cAMP levels below those necessary for PKA activation. 

C- Activation of β-adrenergic receptors causes an increase in cAMP to a level in excess of that which can be degraded by PDE. 

D- The resulting binding of cAMP to the R subunits of PKA releases the active catalytic (C) subunits into the cytosol. Some C subunits enter the nucleus, where they phosphorylate and thus activate certain transcription factors . Other C subunits phosphorylate PDE, stimulating its catalytic activity.

E-  Active PDE hydrolyzes cAMP, thereby driving cAMP levels back to basal levels and causing re-formation of the inactive PKA C-R complex. Subsequent de-phosphorylation of PDE returns the complex to the resting state.

#Question id: 5357

#Unit 8. Inheritance Biology

This pedigree shows the inheritance of a recessive trait in humans. Individuals that have the trait are homozygous for a recessive allele a. If H and I, who happen to be first cousins, marry and have a child, what is the chance that this child will have the recessive trait?

#Question id: 5358

#Unit 8. Inheritance Biology

In the following pedigree, individuals with shaded show presence of a recessive autosomal trait. If all individual is coming from outside the family is homozygous for normal. The calculated risk of occurrence of this trait for (?) individual is 

#Question id: 5359

#Unit 8. Inheritance Biology

Which of the following mode of inheritance and selected individuals must be carrier showing in above pedigree?

#Question id: 5360

#Unit 1. Molecules and their Interaction Relevant to Biology

Following some different genetic disorder traces in families. 

 Which of the following possible mode of inheritance in the Family A, B, C and D respectively

#Question id: 5360

#Unit 8. Inheritance Biology

Following some different genetic disorder traces in families. 

 Which of the following possible mode of inheritance in the Family A, B, C and D respectively

#Question id: 5361

#Unit 8. Inheritance Biology

The pedigree shows the inheritance of a RFLP marker through three generations in a single family. A total of 8 alleles (numbered to the left of the blots) are present in the family. The RFLPs of each member of the family are placed directly below his (squares) or her (circles) symbol and RFLP numbers. In Above pedigree, which of the following are not children of second generation parent?