Choose right explanations of gastrulation movements,  

TLS Online TPP Program

#Question id: 15832

#Unit 8. Inheritance Biology

Your friends Ben and Jane are contemplating having children and seek your genetic counsel. Ben and Jane are unrelated, but both have younger brothers with the same, extremely rare genetic trait. (In fact, Ben and Jane met at a support group meeting for children and families of children with this rare disorder.) Ben’s parents and Jane’s parents are all unaffected.        

 Assume that the trait is autosomal dominant with 80% penetrance in heterozygotes and 100% penetrance in homozygotes. What is the probability that Ben and Jane’s first child will be affected? 

TLS Online TPP Program

#Question id: 18083

#Unit 8. Inheritance Biology

The interaction of selection and inbreeding in determining the incidence of autosomal recessive diseases. Consider a gene in which recessive mutations occur at a rate of 10^-5. Assume a selective disadvantage S of 0.4 in homozygotes for the recessive allele. Would q be expected to rise, fall, or remain unchanged during the first 10 generations after the cessation of inbreeding, Briefly justify your answer. What numerical value would q approach after thousands of generations with no inbreeding?

TLS Online TPP Program

#Question id: 18227

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal dominant disease. You are focused on two SSR markers that may be linked to each other and to the disease. Here is a family in which some individuals are affected:

 

Calculate LOD scores for linkage at θ = 0.1 between the disease and SSR62

TLS Online TPP Program

#Question id: 18228

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal dominant disease. You are focused on two SSR markers that may be linked to each other and to the disease. Here is a family in which some individuals are affected:

 

Calculate LOD scores for linkage at θ = 0.1 between the disease and SSR93?

TLS Online TPP Program

#Question id: 18229

#Unit 8. Inheritance Biology

You are conducting genetic linkage studies of an autosomal dominant disease. You are focused on two SSR markers that may be linked to each other and to the disease. Here is a family in which some individuals are affected:

 

Calculate LOD scores for linkage at θ = 0.1 between SSR62 and SSR93

TLS Online TPP Program

#Question id: 19107

#Unit 8. Inheritance Biology

Assume that mating is random. First, consider an autosomal recessive disease that is usually lethal in childhood, and that has an incidence among newborns of 1/3000.  Perhaps the explanation for the incidence of the disease is heterozygote advantage. How large would this heterozygote advantage have to be (assuming the mutation rate is negligible)?