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TLS Online TPP Program

#Question id: 1364

In mice engineered to overexpress the syndecan-1 gene in the hypothalamic region of the brain and other tissues, normal control of feeding by antisatiety peptides is disrupted, and the animals overeat and become obese. Other studies have shown that syndecan-3 may also be involved in the regulation of feeding behavior. Given the following information, which of these outcomes might you expect in experimentally manipulated mice?

I. Hypothalmic expression of syndecan-3 is increased by fasting.

II. Syndecan-3 knockout mice are resistant to diet-induced obesity.

III. Heparinase can cleave syndecan-3 to release heparin sulfate GAG chains that may suppress the activity of antisatiety peptides and feeding behavior.

Following statements are:

A. Overexpression of heparinase in mice with normal levels of syndecan-3 would result in resistance to diet-induced obesity.

B.  In mice with normal levels of syndecan-3, fasting followed by free access to a high-fat diet would lead to resistance to diet-induced obesity.

C. Lack of heparinase in mice with normal levels of syndecan-3 would result in animals that overeat and become obese.

D. Overexpression of heparinase in syndecan-3 knockout mice would reverse the resistance to diet-induced obesity.

Which of the following combination is correct?

#Unit 4. Cell Communication and Cell Signaling

  1. A and B

  2. B and C

  3. A and C

  4. C and D

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TLS Online TPP Program

#Question id: 18960

#Unit 13. Methods in Biology

cDNA library do not require very large vectors hence which of the following is commonly used in cDNA library
TLS Online TPP Program

#Question id: 18961

#Unit 13. Methods in Biology

When a cDNA library is generated by first removing those mRNA or cDNA sequences that are common to two sources, e.g., two different Cell types, such a library is called 
TLS Online TPP Program

#Question id: 18962

#Unit 13. Methods in Biology

1. Presence of oncogenes (iaaM, iaaH and ipt) in T-DNA,

2. Their large size makes the handling procedures during cloning tedious and cumbersome

3. A general lack of unique cloning sites within the T-DNA, which are needed for the insertion of DNA segments to be cloned.

These three problems have been resolved by deleting 
TLS Online TPP Program

#Question id: 18963

#Unit 13. Methods in Biology

The use of wild type pTi as a vector presents the following three problems.
1. Presence of oncogenes (iaaM, iaaH and ipt) in T-DNA, which causes a disorganised growth and a loss of regeneration potentiaLof the cells having T-DNA in their genomes.
2. Their large size makes the handling procedures during cloning tedious and cumbersome.
3. A general lack of unique cloning sites within the T-DNA, which are needed for the insertion of DNA segments to be cloned
In the above mention’s problems, 1 and 3 can removed by disarming and creating MCS, to overcome from 2nd problem need to develop
TLS Online TPP Program

#Question id: 18964

#Unit 13. Methods in Biology

Size of agrobacterium can be reduced by binary vector formation; these binary vectors can be formed by phenomenon of
TLS Online TPP Program

#Question id: 18969

#Unit 8. Inheritance Biology

Consider the ABO “blood type” gene. This single gene has three alleles called A, B, and O. There are four resultant “blood types” (phenotypic classes), as follows:C
                               
Assume Hardy-Weinberg equilibrium. In Norway, the frequencies of the A and B alleles are 0.26 and 0.07, respectively. What is the frequencies of these six genotypes (AA, AO, BB, BO, AB, and OO);