FOXP1 is a transcription factor which stimulate the production of Oct4 and Nanog and establish pluripotency. Which of the following statements are correct regarding to the mechanism of alternative splicing of FOXP1. 

A. There are two isoforms of the FoxP1 protein, One is the product of an mRNA spliced to include a particular exon, 18b, while the other splicing variant carries exon 18a.

B. When alternative splicing generates a form including exon 18b in place of 18a, the resulting isoform (FOXP1-ES) binds to a different DNA sequence and thus controls expression of a different set of genes.

C. The protein encoded by the exon 18b– carrying mRNA is called FOXP1-ES it fails to stimulate expression of OCT4 and NANOG and instead actives genes that promote differentiation. 

D. The exon 18a– containing form encodes FOXP1 itself, and this has the opposite effect: this activates genes that promote dedifferentiation, and thus stimulates iPS cell formation.

#Question id: 2533

#Unit 2. Cellular Organization

Cellulose microfibrils have an ordered structure and are synthesized at the plasma membrane, given characteristics of microfibrils;

a) Each microfibril is composed of an estimated 18 parallel chains of (1,4)-linked β-D-glucose chains tightly bonded to each other to form a crystalline microfibril

b) Microfibrils have hydrophilic surfaces, populated by polar –OH groups extending from theplane of the sugar rings

c) Microfibrils have hydrophobic surfaces, populated by nonpolar C–H groups populating thesides of stacked glucose chains

 d) microfibril important for enzymatic attack by microbial cellulases, which dock onto the hydrophobic surface and remove one glucan chain at a time

Which of the following from given characterstics of microfibrils is incorrect?

#Question id: 32425

#Unit 2. Cellular Organization

#Question id: 449

#Unit 1. Molecules and their Interaction Relevant to Biology

The standard free-energy changes for the reactions below are given. Phosphocreatine -> creatine + Pi DG'° = –43.0 kJ/mol ATP ->  ADP + Pi DG'° = –30.5 kJ/mol What is the overall DG'° for the following reaction? Phosphocreatine + ADP -> creatine + ATP

#Question id: 2782

#Unit 2. Cellular Organization

Open reading frame (ORF) analysis is not effective in identifying genes in higher eukaryotes because of the presence of

#Question id: 26428

#Unit 3. Fundamental Processes

In human loss of function in MUT S/L OR MSH2-3 complex leads to which of the following phenomenon