If a thymocyte randomly generated a TCR with an affinity for MHC Class I, the TCR and CD8 would bind MHC Class I together, and generate a signal that specifically initiated a program that is 

a) silenced CD8 expression

b) silenced CD4 expression

c) induced expression of genes specific for helper T-cell lineage function

d) induced expression of genes specific for cytotoxic T-cell lineage function

TLS Online TPP Program

#Question id: 15778

#Unit 5. Developmental Biology

Stem cell regulation is highly influenced by the microenvironment that surrounds a stem cell and is known as the

TLS Online TPP Program

#Question id: 15779

#Unit 5. Developmental Biology

During stem cell regulation extracellular mechanisms leading to intracellular changes that regulate stem cell behaviour. Which of the following is not consider as extracellular mechanisms for stem cell regulation?

TLS Online TPP Program

#Question id: 15780

#Unit 5. Developmental Biology

In drosophila, the somatic cells of the hub are able to regulate stem cell proliferation by secreting the paracrine factor Unpaired onto the cells attached to them. Unpaired activates the JAK-STAT pathway in the adjacent germ stem cells to specify their self-renewal. Those cells that are distant from the paracrine factor cannot receive this signal, they begin their differentiation into the sperm cell lineage. This means hub cells act as

TLS Online TPP Program

#Question id: 15781

#Unit 5. Developmental Biology

Chemical regulation of stem cells takes the form of secreted proteins from surrounding cells that influence stem cell states and progenitor differentiation through endocrine, paracrine, or juxtacrine mechanisms. These signaling factors:

TLS Online TPP Program

#Question id: 15782

#Unit 5. Developmental Biology

Adult cells may be reprogrammed to gain pluripotency by modifying the genes namely 

TLS Online TPP Program

#Question id: 15783

#Unit 5. Developmental Biology

During the formation of induced pluripotent stem cell, what is the function of Klf-4?