2 You are studying regulation of the yeast enzyme glutamine synthetase (GS), which is encoded by the GLN1 gene. You have isolated two mutants, designated gln2– and gln3–, that give decreased GS activity. Mating of either gln2– or gln3– haploids to wild type produces heterozygous diploids that show normal amounts of GS expression. When you cross either a gln2– or gln3– haploid to a gln1– strain the resulting diploids show normal expression of GS, that could explain the effect of the gln2– and gln3– mutations on the regulation of GLN1.

The GLN1 gene shows a rather complex regulation in response to different amino acids. When either glutamate (glu) or glutamine (gln) is added to the medium, the amount of GS expression diminished and when both glutamate and glutamine are added to the medium GS expression is shut off completely. The effects of different mutants on the response to glu and gln are shown below.

#Question id: 5719

#Unit 8. Inheritance Biology

Homologous chromosomes pair in prophase I as a following way, if crossingover occur between P and Q gene of homologous chromosome?

Which of the following proceeding event due to this abnormality?

A. Dicentric chromosome become breaks at anaphase I

B. Resulting one of the gamete received chromosome with deleted segment 

C. Recombinant gamete unable to produced viable progeny

D. Unable to separation of chromosome in anaphase II

#Question id: 5720

#Unit 8. Inheritance Biology

Which two of the following are the CORRECT statements ?

P. Nondisjunction in the parental meiosis is not essential to produce diploid organisms

Q. Nondisjunction in the parental meiosis is essential to produce aneuploid organisms

R. Nondisjunction in the parental meiosis is essential to produce hexaploid organism

S. Nondisjunction in the parental meiosis is essential to produce tetraploid organisms

#Question id: 5721

#Unit 8. Inheritance Biology

There is paracentric inversion heterozygote ABCDEFG/ABFEDCG involved in double recombination during meiosis I within inverted region result in

A. dicentric and an acentric chromosome in meiosis I as the chiasmata get terminated.

B. appearance of deletion in both the cross over product

C. all gamete are viable

D. nonviable gametes from crossover products.

Which of the above statements are correct?

#Question id: 5722

#Unit 8. Inheritance Biology

Meiotic products resulting from a single crossover within a pericentric inversion loop

A. This will generate a dicentric and an acentric chromosome following separation of chromosomes after crossing over

B. the inversion will completely suppress crossing over

C. All parental gametes that carry inversion chromosome are nonviable

D. All gametes from crossover products are non viable due to appearance of duplication of one arm and deletion of another arm

Which of the above statements are correct?

#Question id: 5723

#Unit 8. Inheritance Biology

An individual heterozygous for a reciprocal translocation possesses the following chromosomes

I-  nonviability                                  II – Viability        

III- only translocated chromosome     IV- only normal chromosome

V- one translocated another normal

Which of the following above chromosome constituent and feature in their gamete result from?

A- alternate       B- adjacent-1     C- adjacent-2

#Question id: 5724

#Unit 8. Inheritance Biology

Species I is diploid (2n  = 8) with chromosomes

AABBCCDD; related species II is diploid (2n = 8) with chromosomes MMNNOOPP. Individuals with the following sets of chromosomes represent what types of chromosome mutations?

A-   AAABBCCDD        B-   AABBCCDDMNOP

C-   AAABBCCDDD