In what way is tumor progression like biological evolution?

TLS Online TPP Program

#Question id: 34117

#Unit 2. Cellular Organization

A. In the solenoid model, the nucleosomal DNA forms a superhelix containing approximately six nucleosomes per turn

B. In the solenoid model, the linker DNA is buried in the center of the superhelix, but it passes through the axis.

C. Zigzag conformation requires the linker DNA to pass through the central axis of the fiber in a relatively straight form

D. Zigzag conformation the nucleosomal DNA forms a superhelix containing approximately four nucleosomes per turn

Which of the following is correct

TLS Online TPP Program

#Question id: 34118

#Unit 2. Cellular Organization

A. Trypsin treated core histones quickly forms 30-nm fibers

B. Core histones lacking their amino-terminal tails are incapable of forming 30-nm fibers

C. Interaction between the positively charged amino terminus of histone H4 and a negatively charged region of the histone-fold domain of histone H2A is particularly important for 30-nm fiber formation

D. H2A that interact with the H4 tail are conserved across many eukaryotic organisms but are not involved in DNA binding or formation of the histone octamer.

Choose true and false

TLS Online TPP Program

#Question id: 34119

#Unit 2. Cellular Organization

30-nm fiber forms loops of 40–90 kb that are held together at their bases by a proteinaceous structure referred to as the nuclear scaffold. These are stabilised by

TLS Online TPP Program

#Question id: 34120

#Unit 2. Cellular Organization

The dynamic nature of DNA binding to the histone core structure is important, because many DNA-binding proteins strongly prefer to bind to histone-free DNA. Such proteins can recognize their binding site only when it is released from the histone octamer or is contained in linker or nucleosome-free DNA.

Which of the following statement stands untrue for above fact

TLS Online TPP Program

#Question id: 34121

#Unit 2. Cellular Organization

Replication independent assembly of histones is catalysed by

TLS Online TPP Program

#Question id: 34122

#Unit 7. System Physiology – Animal

Loss of which of the following pituitary hormones might be expected to increase responses to painful stimuli?