There is evidence that the accumulation of abnormal or damaged proteins due to impairment of the pathway contributes to a number of neurodegenerative diseases, including Alzheimer’s. In contrast, deliberately blocking the pathway in cancer cells could lead to a disruption of protein regulation that in turn could cause the apoptosis of the malignant cells. Accordingly, proteasome inhibitors have been developed for evaluation as anti-tumour agents against selected cancers. Bortezomib is one such inhibitor that targets the 26S proteasome, and in combination with other chemotherapeutic agents has been shown to have therapeutic potential. In contrast to the long-term control, there are several mechanisms by which the activity of an enzyme can be altered almost instantaneously:

A. Reversible inhibition by small molecules (drugs)

B. Product inhibition

C. Allosteric regulation

D. Reversible covalent modification

Which of the above mechanism follow the process of negative-feedback control and ADP-ribosylation respectively?

TLS Online TPP Program

#Question id: 12469

#Unit 10. Ecological Principles

A population of strictly monogamous swans consists of 40 males and 10 females. What is the effective population size (ne) for this population?

TLS Online TPP Program

#Question id: 12470

#Unit 10. Ecological Principles

An ecologist recorded 12 white-tailed deer, Odocoileus virginianus, per square mile in one woodlot and 20 per square mile on another woodlot. What was the ecologist comparing?

TLS Online TPP Program

#Question id: 12471

#Unit 10. Ecological Principles

To measure the population density of monarch butterflies occupying a particular park, 100 butterflies are captured, marked with a small dot on a wing, and then released. The next day, another 100 butterflies are captured, including the recapture of 20 marked butterflies. One would estimate the population to be

TLS Online TPP Program

#Question id: 12472

#Unit 10. Ecological Principles

During the spring, you are studying the mice that live  in  a  field  near your home. There are lots  of  mice in  this field, but you realize that you rarely observe any reproductive females. This most likely indicates

TLS Online TPP Program

#Question id: 12473

#Unit 10. Ecological Principles

You are observing a population of lizards when you notice that the number of adults has increased and is higher than previously observed. One explanation for such an observation would include

TLS Online TPP Program

#Question id: 12474

#Unit 10. Ecological Principles

The most common kind of dispersion in nature is