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TLS Online TPP Program

#Question id: 1513

The kinase activity of ATM is activated in response to DNA damage due to various stresses (e.g., UV irradiation, heat). Activated ATM then triggers following pathways leading to arrest in G1.

A. Chk2 is phosphorylated and, in turn, phosphorylates Cdc25A, thereby marking it for degradation and blocking its role in CDK2 activation.

B. Phosphorylation of p53 stabilizes it, permitting p53-activated expression of genes encoding proteins that cause arrest in G1, promote apoptosis, or participate in DNA repair.

C. Controlling the pool of p53, ATM phosphorylates MDM2 to inactivate it, causing increased stabilization of p53. Another protein p14ARF inhibits the activity of Mdm2 thus stabilizing p53.

Based on the above information, which one of the following statements is correct?

#Unit 4. Cell Communication and Cell Signaling

  1. Gain-of-function of p14ARF and Loss-of-function of p53 leads to tumor formation.

  2. Gain-of-function of p53 and Loss-of-function of Chk2 leads to tumor formation.

  3. Gain-of-function of Cdc25A and Loss-of-function of Chk2 leads to tumor formation.

  4. Gain-of-function of Chk2 and Loss-of-function of MDM2 leads to tumor formation.

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TLS Online TPP Program

#Question id: 7519

#General Aptitude

Two trains start from A and B respectively and travel towards each other at the speeds of 60 km/h and 45 km/h respectively. By the time they meet, the first train has travelled 30 km more than the second. The distance between A and B is
TLS Online TPP Program

#Question id: 7520

#General Aptitude

A train X leaves P at 6 am and reaches Q at 10 am. Another train Y leaves Q at 8 am reaches P at 11.30 am. At what time do the two trains cross each other?
TLS Online TPP Program

#Question id: 7521

#General Aptitude

A man takes 4 h 20 min in walking to a certain place and riding back. He would have gained 1 h 30 min by riding both ways. The time he would take to walk both ways is
TLS Online TPP Program

#Question id: 7522

#General Aptitude

A worker may claim Rs 15 each km which he travels by taxi and Rs 5 for each km which he drives his own car. If in one week he claimed Rs 500 for travelling 80 km, how many km did he travel by taxi?
TLS Online TPP Program

#Question id: 7523

#General Aptitude

A, B and C are three participants in a kilometer race. If A can give B a start of 40 m and B can give C a start of 25 m, how many meters of a start can A give to C?
TLS Online TPP Program

#Question id: 7524

#General Aptitude

City X is at a distance of 560 km from City Y. A train starts from City Y to City X at 6 a.m. with a speed of 40 kmph. Another train starts from City X to City Y at 7 a.m. with a speed of 60 kmph. At what distance from City Y will the two trains be at the point of crossing?