Following statements are regarding to the some cancers harbor characteristic chromosome alterations. Chronic myelogenous leukemia (CML), a common leukemia in humans, was found to be associated with the Philadelphia chromosome.

A. Philadelphia chromosome is generated by a translocation between chromosomes 22 and 9. The two chromosomes exchange their terminal regions, which leads to a characteristic alteration in the size of chromosome 9.

B. At the breakpoint of this translocation, a new fusion protein, the BCR-ABL fusion, is generated.

C. The BCR-ABL fusion protein is a constitutively active kinase that phosphorylates multiple signal-transducing proteins.

D. If this translocation occurs in a hematopoietic cell in the bone marrow, the activity of the chimeric BCR-ABL oncogene dephosphorylate proteins thereby activating many intracellular signal-transducing proteins.

Which of the following statements are incorrect?

#Question id: 3579

#Unit 8. Inheritance Biology

Following some statement is correct with monohybrid and Dihybrid cross?

A) Two alleles for gene segregate into gametes in equal proportions.

B) Monohybrid F2 phenotype 1:2:1 ratio conclude, there is no segregation in character

C)  Monohybrid F2 phenotype 3:1 ratio conclude, there is a no blending inheritance

D) Dihybrid F 2 phenotype 3:1 ratio conclude complete linkage

#Question id: 3580

#Unit 8. Inheritance Biology

Different genetic cross regarding two independently assorting non allelic gene with complete dominance and their phenotypic ratio showed in a following. Which of the following is incorrect combination? 

#Question id: 3581

#Unit 8. Inheritance Biology

What is the probability that each of the following pairs of parents will produce the indicated offspring? (Assume independent assortment of all gene pairs.)

(a) AABBCc X  aabbcc → AaBbCc          (b) AABbCc  X AaBbCc → AAbbCC

(c) AaBbCc  X AaBbCc → AaBbCc         (d) aaBbCC  X  AABbcc → AaBbCc

#Question id: 3582

#Unit 8. Inheritance Biology

Different genetic cross regarding two independently assorting non allelic gene with complete dominance and their phenotypic ratio showed in a following is correc

#Question id: 3583

#Unit 8. Inheritance Biology

In sesame plants, the one-pod condition (P) is dominant to the three-pod condition (p), and normal leaf (L) is dominant to wrinkled leaf (l). Pod type and leaf type are inherited independently. Determine the genotypes for the two parents for all possible cross producing the following offspring:

(a) 300 one-pod, normal leaf and 100 one-pod, wrinkled leaf

(b) 323 three-pod, normal leaf and 106 three-pod, wrinkled leaf

(c) 150 one-pod, normal leaf, 147 one-pod, wrinkled leaf, 51 three-pod, normal leaf, and 48 three-pod, wrinkled leaf

(d) 223 one-pod, normal leaf, 72 one-pod, wrinkled leaf, 76 three-pod, normal leaf, and 27 three-pod, wrinkled leaf

#Question id: 3584

#Unit 8. Inheritance Biology

In a plant species, a segregating line (RR- Red, Rr- Pink and rr- white) that contains both homozygotes and heterozygotes at a locus can be made homozygous by repeated selfing for several generations. What is the proportional red flower in third generations of selfing, if the level of heterozygosity in generation '0' is denoted as 1?