Following statements are regarding to enzymatic processing of benzo(a)pyrene to a more potent mutagen and carcinogen.

A. Liver enzymes, particularly P-450 enzymes, modify benzo(a)pyrene in a series of reactions, producing 7,8-diol-9,10-epoxide, a highly potent mutagenic species that reacts with DNA primarily at the N2 atom of a guanine base.

B. The adduct, (+)-trans-anti-B(a)P-N2-dG, causes polymerase to insert an A rather than a C opposite the modified G base. Next time the DNA is replicated, a T will be inserted opposite the A, and the mutation will be complete.

C. Potent mutagen majorly causes conversion of guanine (G) to thymine (T) bases, a transition mutation.

D. When this potent mutagen applied to cultured bronchial epithelial cells, activated benzo(a)pyrene induces many mutations, including activating mutations at codons 175, 248, and 273 of the p53 gene.

Which of the following statements are correct?

TLS Online TPP Program

#Question id: 28767

#Unit 2. Cellular Organization

Plant vacuole act as__

a) storage organelle for nutrients and waste products

b) degradative compartment

c) an economical way of decreasing cell size

d) a controller of turgor pressure

TLS Online TPP Program

#Question id: 28768

#Unit 2. Cellular Organization

Given following paths from different sources feed substances into lysosomes for digestion, find out the A, B and C?

TLS Online TPP Program

#Question id: 28769

#Unit 2. Cellular Organization

Autophagy occurs in the following sequence of steps___

a) Nucleation of autophagosome formation by ATG9

b) Digestion of the inner membrane and the luminal contents of the autophagosome.

c) Fusion of the autophagosome with lysosomes, catalyzed by SNAREs.

d) Induction by inhibition of mTOR complex 1

e) Closure of the membrane cup to form autophagosome

TLS Online TPP Program

#Question id: 28770

#Unit 2. Cellular Organization

Autophagy can be either;

I- Nonselective autophagy

II- Selective autophagy

a) Closure of the membrane cup to form autophagosome

b) a bulk portion of cytoplasm is sequestered in autophagosomes

c) used to destroy invading microbes

d) Nucleation of autophagosome formation by ATG1

Find out the correct match statements of about selective as well as nonselective autophagy?

TLS Online TPP Program

#Question id: 28771

#Unit 2. Cellular Organization

Which of the following sorting signal that directs lysosomal hydrolases from the TGN to the late endosome?

TLS Online TPP Program

#Question id: 28772

#Unit 2. Cellular Organization

M6P residues are generated in the cis-Golgi by which of the following Golgi-resident enzymes?

a) N-acetylglucosamine (GlcNAc) phosphotransferase

b) ornithine transcarbamylase 

c) Phosphodiesterase

d) Catalases