#Question id: 1522

Conversion of a proto-oncogene into an oncogene, also called activation, generally involves a gain-of-function mutation. Following statements are regarding to the mechanisms that produce oncogenes from the corresponding proto-oncogenes.

A. A change in a single base pair in a proto-oncogene that results in a hyperactive or constitutively active protein product.

B. A chromosomal translocation that fuses two genes together to produce a hybrid gene encoding a chimeric protein whose activity, unlike that of the parent proteins, is permanently suppress.

C. A chromosomal translocation that brings a growth regulatory gene under the control of alternative enhancers that cause inappropriate expression of the gene.

D. Amplification of a DNA segment including a proto-oncogene so that numerous copies exist, leading to overproduction of the encoded protein.

Which of the following statements are correct?