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TLS Online TPP Program

#Question id: 1528

Mutation of p53 is described as a dominant-negative mutation. Which of the following statement is correct regarding to the mechanism by which this mutation causes the dominant-negative phenotype?

#Unit 4. Cell Communication and Cell Signaling

  1. Mutation of p53 is a dominant-negative mutation because the active protein is a dimer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.

  2. Mutation of p53 is a dominant-negative mutation because the active protein is a pentamer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.

  3. Mutation of p53 is a dominant-negative mutation because the active protein is a tetramer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.

  4. Mutation of p53 is a dominant-negative mutation because the active protein is a heptamer of identical subunits; the presence of even one defective subunit in the complex abrogates its function.

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TLS Online TPP Program

#Question id: 19787

#Unit 13. Methods in Biology

Polymerase chain reaction is based on___
a) Thermal modulation
b) pH dependent
c) Formation of amplicons by inserting some inputs for analysing its efficiency
d) Inter-complementary primers formation
TLS Online TPP Program

#Question id: 31213

#Unit 4. Cell Communication and Cell Signaling

Following genes play an essential role in controlling apoptosis during C. elegans development, except: 
TLS Online TPP Program

#Question id: 10384

#Unit 6. System Physiology – Plant

Nitrogenase enzyme complex catalyzes the molecular nitrogen fixation, this enzyme not only fixes nitrogen but also perform other reactions given below. Which one is not performed by nitrogenase?
TLS Online TPP Program

#Question id: 30106

#Unit 1. Molecules and their Interaction Relevant to Biology

If a cell has an adequate supply of adenine nucleotides but requires more guanine nucleotides for protein synthesis:

1. Glutamine-PRPP amidotransferase will not be fully inhibited.
2. AMP will be a feedback inhibitor of the condensation of IMP with aspartate.
3. ATP will stimulate the production of GMP from IMP.
4. ATP will inhibit nucleoside diphosphate reductase.
TLS Online TPP Program

#Question id: 19362

#Unit 13. Methods in Biology

What is the size of fragments that can be obtained by using a phagemid vector?