The interaction of selection and inbreeding in determining the incidence of autosomal recessive diseases. Consider a gene in which recessive mutations occur at a rate of 10^-5. Assume a selective disadvantage S of 0.4 in homozygotes for the recessive allele. Now assume that, for thousands of generations, 10% of all children have been products of first-cousin matings (the remaining 90% being products of random matings). Calculate the steady-state value of q. Also calculate the incidence of the disease at steady state. 

#Question id: 6592

#General Aptitude

#Question id: 7575

#General Aptitude

#Question id: 10231

#Unit 10. Ecological Principles

Character displacement is results of competition that its operates on a

#Question id: 1513

#Unit 4. Cell Communication and Cell Signaling

The kinase activity of ATM is activated in response to DNA damage due to various stresses (e.g., UV irradiation, heat). Activated ATM then triggers following pathways leading to arrest in G1.

A. Chk2 is phosphorylated and, in turn, phosphorylates Cdc25A, thereby marking it for degradation and blocking its role in CDK2 activation.

B. Phosphorylation of p53 stabilizes it, permitting p53-activated expression of genes encoding proteins that cause arrest in G1, promote apoptosis, or participate in DNA repair.

C. Controlling the pool of p53, ATM phosphorylates MDM2 to inactivate it, causing increased stabilization of p53. Another protein p14ARF inhibits the activity of Mdm2 thus stabilizing p53.

Based on the above information, which one of the following statements is correct?

#Question id: 3836

#Unit 3. Fundamental Processes

Which of the following statements accurately describes the differences between DNA replication in prokaryotes and DNA replication in eukaryotes?