You are conducting genetic linkage studies of an autosomal recessive disease whose chromosomal location has not been firmly established. You are focused on two SSR markers that may be linked to each other and to the disease. Here are two families in which some individuals are affected:

 

Calculate LOD scores for linkage at θ= 0.02 between the disease and SSR43 in Family 2.

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#Question id: 24220

#Unit 1. Molecules and their Interaction Relevant to Biology

Glucagon stimulates cAMP from ATP. Cyclic AMP then activates cAMP-dependent protein kinase, phosphorylates PFK-2/FBPase-2. Phosphorylation of this protein enhances its FBPase-2 activity and inhibits its PFK-2 activity resulting

TLS Online TPP Program

#Question id: 24221

#Unit 1. Molecules and their Interaction Relevant to Biology

Glucagon lowers the cellular level of fructose 2,6 bisphosphate by

TLS Online TPP Program

#Question id: 24222

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following reaction of glycolysis is irreversible

1. Glucose is converted to glucose 6-phosphate in the presence of the enzyme hexokinase.

2. Fructose 6-phosphate is converted to fructose 1,6-biphosphate in the presence of the enzyme phosphofructokinase.

3. Phosphoenolpyruvate is converted to pyruvate in the presence of the enzyme pyruvate kinase.

4. isomerization of glucose 6-phosphate to fructose 6-phosphate

TLS Online TPP Program

#Question id: 24223

#Unit 1. Molecules and their Interaction Relevant to Biology

Phosphoglycerate mutase catalyses a reversible shift of the phosphoryl group between C-2 and C-3 of glycerate; which of the following ion is essential for this reaction

TLS Online TPP Program

#Question id: 24224

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following can be synthesized from pyruvate in one step, allosterically inhibits pyruvate kinase, slowing the production of pyruvate by glycolysis

TLS Online TPP Program

#Question id: 24225

#Unit 1. Molecules and their Interaction Relevant to Biology

Choose the incorrect option