#Question id: 15306
#Unit 4. Cell Communication and Cell Signaling
The transformation of a normal cell to a cancer cell is accompanied by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;
|
Gene |
Primary tumor |
Proposed function |
|
i) APC |
Colorectal |
Binds β
‐catenin acting as transcription factor |
|
ii) BRCA1 |
Breast |
DNA repair |
|
iii) MSH2, MLH1 |
Melanoma, pancreatic |
p16: Cdk inhibitor ARF: stabilizes p53 |
|
iv) E‐Cadherin |
Breast, colon |
Cell adhesion molecule |
|
v) INK4a |
Colorectal |
Mismatch repair |
|
vi) NF1 |
Neurofibromas |
Activates GTPase of Ras |
Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions; |
#Question id: 3880
#Unit 3. Fundamental Processes
Which one of the following properties of the L-19 IVS ribozyme is not shared with enzymes that are purely protein?
#Question id: 32346
#Unit 1. Molecules and their Interaction Relevant to Biology
#Question id: 603
#Unit 1. Molecules and their Interaction Relevant to Biology
Nonclassical competitive inhibition involves ________.
#Question id: 5720
#Unit 8. Inheritance Biology
Which two of the following are the CORRECT statements ?
P. Nondisjunction in the parental meiosis is not essential to produce diploid organisms
Q. Nondisjunction in the parental meiosis is essential to produce aneuploid organisms
R. Nondisjunction in the parental meiosis is essential to produce hexaploid organism
S. Nondisjunction in the parental meiosis is essential to produce tetraploid organisms