TLS Online TPP Program

#Question id: 19737


Choose the incorrect statement regarding telomerase 

#Unit 3. Fundamental Processes
  1. Telomerase require 3’OH DNA primer to synthesised DNA over RNA template 
  2. For the synthesis of telomere by telomerase require dATP, dGTP, dCTP, and dTTP
  3. The telomerase is a large ribonucleoprotein that consists of a templating RNA encoded by TLC1 in yeast, hTERC in humans
  4. Telomerase synthesizes the individual repeats that are added to the chromosome ends, but does not itself control the number of repeats
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TLS Online TPP Program

#Question id: 19722

#Unit 3. Fundamental Processes

Telomerase, a reverse transcriptase that contains an RNA template, repeatedly adds 

TLS Online TPP Program

#Question id: 19723

#Unit 3. Fundamental Processes

Reduction in the telomerase activity after the cell cycle is the notion of 
a) Cell ageing
b) Senescence 
c) Apoptosis

TLS Online TPP Program

#Question id: 19733

#Unit 3. Fundamental Processes

Extensive shortening of telomeres eventually leads to 

TLS Online TPP Program

#Question id: 19734

#Unit 3. Fundamental Processes

Some of the statements are given regarding shelterin choose the correct 
a) Shelterin is the complex of telomeric protein
b) Shelterin functions to protect telomeres from DNA damage repair pathways
c) In mammals, six telomeric proteins (TRF1, TRF2, Rap1, TIN2, TPP1, and POT1) comprises a complex.
d) Shelterin also regulate telomere length control by telomerase

TLS Online TPP Program

#Question id: 19735

#Unit 3. Fundamental Processes

In mammals, six telomeric proteins (TRF1, TRF2, Rap1, TIN2, TPP1, and POT1) comprises a complex which of the following is incorrect regrarding these telomeric protein
a) TRF1, TRF2, Rap1, binds to double stranded of DNA
b) TIN2 does not binds to DNA at all
c) POT1 binds to the GT tail extended by telomerase
d) TIN2 interacts with the two duplex telomeric DNA-binding proteins TRF1 and TRF2 as well as with TPP1

TLS Online TPP Program

#Question id: 19736

#Unit 3. Fundamental Processes

Which of the following shelterin protein interacts with the two duplex telomeric DNA-binding proteins TRF1 and TRF2 as well as with TPP1