#Question id: 1136
#Unit 4. Cell Communication and Cell Signaling
Which of the following signaling pathways can be activated by activation of receptor tyrosine kinases?
a. phospholipase Cγ b. PI-3 kinase
c. MAP kinase d. none of the above
#Question id: 23889
#Unit 13. Methods in Biology
#Question id: 1257
#Unit 4. Cell Communication and Cell Signaling
Following statements are regarding to protein kinase A which phosphorylates multiple intracellular target proteins expressed in different cell types.
A. Inactive PKA is a tetramer consisting of two regulatory (R) subunits and two catalytic (C) subunits.
B. Each R subunit contains a pseudo-substrate domain whose sequence resembles that of a peptide substrate and binds to the active site in the catalytic domain but is not phosphorylated; thus the pseudo-substrate domain inhibits the activity of the catalytic subunits.
C. active PKA is turned off by binding of cAMP Each R subunit has two distinct cAMP-binding sites, called CNB-A and CNB-B.
D. Binding of cAMP by an R subunit of PKA occurs in a cooperative fashion; that is, binding of the first cAMP molecule to CNB-B increases the Kd for binding of the second cAMP to CNB-A. Thus small changes in the level of cytosolic cAMP can cause proportionately large changes in the number of dissociated C subunits and, hence, in cellular kinase activity.
Which of the following statements are incorrect?
#Question id: 6952
#Unit 5. Developmental Biology
Which technique is commonly used for gene knock-out in mice?
#Question id: 10299
#Unit 6. System Physiology – Plant
The stages of respiration take place within an organelle enclosed by a double membrane, the mitochondrion. Which of the following processes occur only inside the mitochondria?