#Question id: 21246
#Unit 7. System Physiology – Animal
#Question id: 7451
#General Aptitude
#Question id: 1244
#Unit 4. Cell Communication and Cell Signaling
Which type of experimental evidence shows that the intrinsic GTPase activity of the Gα subunit is important for terminating effector activation?
#Question id: 13195
#Unit 1. Molecules and their Interaction Relevant to Biology
#Question id: 2973
#Unit 2. Cellular Organization
Following statements are regarding to the spindle position checkpoint pathway in budding yeast.
A. During interphase and early mitosis, Cdc14 is sequestered and inactivated in the nucleolus. Inactive Tem1-GDP associates with the spindle pole body (SPB) nearest to the bud as soon as the mitotic spindle forms.
B. If chromosome segregation occurs properly, extension of the spindle microtubules inserts the daughter SPB into the bud, causing Tem1 to be activated by an unknown mechanism.
C. Tem1-GDP activates a protein kinase cascade, which then promotes the release of active Cdc14 from the nucleolus and exit from mitosis.
D. If the spindle apparatus fails to place the daughter SPB in the bud, Kin4 (cyan), an inhibitor of Tem1, is recruited from the parent cell cortex to the parent-cell-located SPB and maintains Tem1 in the GTP-bound form, and mitotic exit does not occur.
Which of the following are correct?