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TLS Online TPP Program

#Question id: 2551

Gaucher disease is the most common of lipid storage diseases in humans. It is caused by a deficiency of an enzyme necessary for the breakdown of lipids. This leads to the accumulation of fatty material in organs of the body including the spleen, liver, kidneys, lungs, brain, and bone marrow. Using your knowledge of the structure of eukaryotic cells, identify the statement below that best explains how internal membranes and the organelles of cells may be involved in Gaucher disease.

#Unit 2. Cellular Organization

  1. The mitochondria are most likely defective and do not produce adequate amounts of ATP needed for cellular energy.

  2. The rough endoplasmic reticulum contains too many ribosomes, which results in an overproduction of the enzyme involved in lipid breakdown.

  3. The lysosomes lack sufficient amounts of enzymes necessary for the metabolism of lipids.

  4. The Golgi apparatus produces vesicles with faulty membranes, which fail to be transported to the plasma membrane for secretion.

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TLS Online TPP Program

#Question id: 27941

#Unit 1. Molecules and their Interaction Relevant to Biology

Some of the following statement are made regarding the Enzymes of glycolysis along with their Coenzyme (s) or Cofactor (s) and Inhibitor (s)

a. Phosphoglucoisomerase having Mg2+ as Cofactor and can be inhibited by 2-deoxyglucose 6-phosphate
b. Aldolase having Zn2+ as Cofactor, can be inhibited by Chelating agents
c. Enolase having Mg, Mn22+ Cd2 as Cofactor, can be inhibited by Fluoride + phosphate
d. Phosphofructokinase having NAD as Coenzyme can be inhibited by Iodoacetate
Which of the following is correct
TLS Online TPP Program

#Question id: 27942

#Unit 1. Molecules and their Interaction Relevant to Biology

Glycolytic enzymes along with them their class is mentioned  
(1) Phosphoglucoisomerase, Phosphotriose isomerase, Phosphoglycerate mutase belongs to Isomerases 
(2) Hexokinase, Phosphofructokinase, Phosphoglycerate kinase, Pyruvate kinase belongs to Transferases 
(3) Aldolase, Enolase belongs to Lysases 
(4) Glyceraldehyde 3-phosphate dehydrogenase belongs to Oxidoreductases

Which of the following is correct
TLS Online TPP Program

#Question id: 27943

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following reaction is catalyzes by enolase during Glycolysis
TLS Online TPP Program

#Question id: 27944

#Unit 1. Molecules and their Interaction Relevant to Biology

Which one of the following is not the component of Co-A
TLS Online TPP Program

#Question id: 27945

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following statements is true regarding the payoff phase of glycolysis

a. Each molecule of glyceraldehyde 3-phosphate is oxidized and phosphorylated by ATP to form 1,3-bisphosphoglycerate 

b. Each molecule of glyceraldehyde 3-phosphate is oxidized and phosphorylated by inorganic phosphate to form 1,3-bisphosphoglycerate

c. Oxidative phosphorylation of 3-Phosphoglycerate produces one NADH

d. Oxidative phosphorylation of glyceraldehyde 3-phosphate, produces one NADH
TLS Online TPP Program

#Question id: 27946

#Unit 1. Molecules and their Interaction Relevant to Biology

The overall equation for glycolysis is