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TLS Online TPP Program

#Question id: 2916

Which of the following statement is INCORRECT regarding the packaging of DNA into higher order chromatin structure?

#Unit 2. Cellular Organization

  1. One of the two regions bound by H1 is the linker DNA at one end of the nucleosome. The second site of DNA binding is in the middle of the associated 147 bp (the only DNA duplex present at the dyad axis).

  2. Core histones that had undergone nuclease treatment are capable of forming 30-nm fibers. The most likely role of the tails is to stabilize the 30-nm fiber by interacting with adjacent nucleosomes.

  3. 30-nm fiber forms loops of 40–90 kb that are held together at their bases by a proteinaceous structure referred to as the nuclear scaffold abundant in Topoisomerase-II and SMC proteins.

  4. Positioning a nucleosome allows the DNA binding site for a regulatory protein to remain in the accessible linker DNA region as tightly positioned nucleosomes are most often found at sites directing the initiation of transcription.

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TLS Online TPP Program

#Question id: 11466

#Unit 1. Molecules and their Interaction Relevant to Biology

Calculate the PI of histidine ?
TLS Online TPP Program

#Question id: 14713

#Unit 5. Developmental Biology

Match their cleavage patterns with their belonging animals;
TLS Online TPP Program

#Question id: 14081

#Unit 1. Molecules and their Interaction Relevant to Biology

pKa of cytosine normally has a value of 4.2 but in hoogsteen triple base pairing this value changes to 
TLS Online TPP Program

#Question id: 15276

#Unit 13. Methods in Biology

At high salt concentrations, the mRNA containing poly(A) tails binds to the complementary oligo(dT) molecules of the affinity column, and so, mRNA will be retained; all other RNA molecules can be washed through the column by further high salt solution. finally, the bound mRNA can be eluted by using
TLS Online TPP Program

#Question id: 6988

#Unit 5. Developmental Biology

Many cells in the body divide only rarely, if at all; neurons, red blood cells, and keratinocytes are extreme examples. In which portion of the cell cycle would such cells be considered to be?