The mitotic exit network that localizes to spindle pole bodies and whose activity is regulated by spindle position belongs to the family of signaling pathways known as the Hippo pathway in metazoans. Following statements are-

A. The conserved core of the Hippo signaling pathways consists of the Hippo protein kinase, which activates the Lats-Mob1 kinase.

B. The kinases are organized by a scaffolding molecule that, at least in budding and fission yeasts, targets the kinase cascade to centrosomes.

C. As in many kinase signaling cascades, a GTPase controls the activity of the mitotic exit network and the septation initiation network.

D. In metazoans, activation of the Hippo pathway leads to tissue overgrowth because the transcriptional activator TAZ (known as YAP in the mouse) constitutively promotes the expression of growth- and proliferation-promoting genes.

Which of the following statements are incorrect?

TLS Online TPP Program

#Question id: 15419

#Unit 5. Developmental Biology

Doris Taylor’s research group used detergents to remove all the cells from a cadaveric rat heart, which leaves behind the natural extracellular matrix. An extracellular matrix scaffold can promote the differentiation and rebuilding of a beating heart. The researchers then infused this ECM scaffold with cardiomyocytes. Now these cells differentiated and organized into a functionally contracting “recellularized” heart. Which of the following statement is correct?

TLS Online TPP Program

#Question id: 15420

#Unit 5. Developmental Biology

signal from the inducing cell is necessary for initiating new gene expression in the responding cell. Without the inducing cell, the responding cell is not capable of differentiating in that particular way, phenomena known as:

TLS Online TPP Program

#Question id: 15421

#Unit 5. Developmental Biology

A signal from the inducing cell is necessary for initiating new gene expression in the responding cell. Without the inducing cell, the responding cell is not capable of differentiating in that particular way, phenomena known as:

TLS Online TPP Program

#Question id: 15422

#Unit 5. Developmental Biology

During Vulval induction in C. elegans, the anchor cell secretes, a paracrine factor which receives by VPCs and become vulva. If the anchor cell is destroyed, the VPCs will not form a vulva. This is the example of:

TLS Online TPP Program

#Question id: 15441

#Unit 4. Cell Communication and Cell Signaling

In hermaphrodites, expression of the egl-1 gene in the neurons is repressed by the transcription factor, and deletion of that causes these neurons to undergo apoptosis;

TLS Online TPP Program

#Question id: 15442

#Unit 4. Cell Communication and Cell Signaling

XIAP, one member of a family of inhibitor of apoptosis proteins (IAPs), provides another way to restrain both initiator and effector caspases; Find out the INCORRECT statements about this inhibitor-