Start with a collection of mutants obtained using selections or screens and then characterize their wild functions at the molecular level called ----A------, alternatively, start with a set of specific DNA sequences, mutate them, and observe the phenotypes called --B-----.

TLS Online TPP Program

#Question id: 28620

#Unit 2. Cellular Organization

APC/C works with core and substrate-targeting factors, the core is organized into several different modules, except?

TLS Online TPP Program

#Question id: 28621

#Unit 2. Cellular Organization

Substrate-targeting subunits of the APC/C recognize specific sequence motifs on the proteins that the APC/C ubiquitinates. One motif the destruction box or D-box, has the consensus sequence is___

TLS Online TPP Program

#Question id: 28622

#Unit 2. Cellular Organization

What will cause if mutating or deleting the destruction box in mitotic cyclins? 

a) Allows loading of MCM helicases

b) prevented mitotic cyclins ubiquitinylation

c) blocked mitotic cells from exiting mitosis

d) inhibition of re-initiation at origins

TLS Online TPP Program

#Question id: 28623

#Unit 2. Cellular Organization

At which phase of APC/C bound to Cdc20 targets protein for degradation? 

TLS Online TPP Program

#Question id: 28624

#Unit 2. Cellular Organization

Ubiquitin protein-ligases APC/CCdc20  performs various functions such as  

a) Degradation of geminin

b) Degradation of securin

c) Induce degradation of B-type cyclin

d) Allows chromosomal separation

Which of the following is incorrect about APC/CCdc20

TLS Online TPP Program

#Question id: 28625

#Unit 2. Cellular Organization

Ubiquitin protein-ligases APC/CCdh1  performs various functions such as  

a) Degradation of geminin

b) Degradation of securin

c) Induce degradation of B-type cyclin in G1

d) Allows loading of  replicative helicase 

Which of the following is incorrect about APC/CCdh1