#Question id: 5079
#Unit 5. Developmental Biology
The pattern of embryonic development in which only the cells lacking yolk subsequently undergo cleavage is called:
#Question id: 26512
#Unit 3. Fundamental Processes
#Question id: 11840
#Unit 1. Molecules and their Interaction Relevant to Biology
During an ethylene signalling pathway, what will have done inside cytosol and nucleus . Given below some
prediction about presence and absence of ethylene in column B match with column
A
COLUMN A |
COLUMN B |
I- In the presence of ethylene |
a) ETR1 signaling is repressed and CTR1 is
inactive |
II-
In the absence of ethylene |
b) ETR1 activate CTR1, a Ser/Thr kinase |
|
c) CTR1 phosphorylates the C-terminal domain
of EIN2 |
|
d) The nonphosphorylated C terminus of EIN2 is
cleaved by a protease |
|
e) Phosphorylation of EIN2 inhibits
proteolytic cleavage |
|
f) EIN3 transcription factors are
ubiquitinated and degraded in the nucleus by the 26S proteasome |
|
g) EIN3 initiates a transcriptional cascade by
activating expression of ethylene-responsive genes, including ERF1
transcription factor, leading to ethylene responses |
#Question id: 7120
#Unit 5. Developmental Biology
Which of the following is the only true statement regarding compaction in the mouse embryo?
#Question id: 1512
#Unit 4. Cell Communication and Cell Signaling
There is evidence that the accumulation of abnormal or damaged proteins due to impairment of the pathway contributes to a number of neurodegenerative diseases, including Alzheimer’s. In contrast, deliberately blocking the pathway in cancer cells could lead to a disruption of protein regulation that in turn could cause the apoptosis of the malignant cells. Accordingly, proteasome inhibitors have been developed for evaluation as anti-tumour agents against selected cancers. Bortezomib is one such inhibitor that targets the 26S proteasome, and in combination with other chemotherapeutic agents has been shown to have therapeutic potential. In contrast to the long-term control, there are several mechanisms by which the activity of an enzyme can be altered almost instantaneously:
A. Reversible inhibition by small molecules (drugs)
B. Product inhibition
C. Allosteric regulation
D. Reversible covalent modification
Which of the above mechanism follow the process of negative-feedback control and ADP-ribosylation respectively?