One successful form of gene therapy has involved delivery of an allele for the enzyme adenosine deaminase (ADA) to bone marrow cells of a child with SCID, and delivery of these engineered cells back to the bone marrow of the affected child. What is one major reason for the success of this procedure as opposed to many other efforts at gene therapy?

#Question id: 4273

#Unit 3. Fundamental Processes

80S initiation complex includes

#Question id: 4274

#Unit 3. Fundamental Processes

One mechanism that contributes to the fidelity of codon recognition involves the 16S rRNA other than initiation. Which of the following statements are correct in this phenomenon?

A. Codon recognition involves two adjacent uracil residues in the 16S rRNA component

B. The adjacent residues in the 16S rRNA do not discriminate between G:C or A:U base pairs and recognize either as correct

C. Even a single mismatch in the codon–anticodon base pairing alters the position of EF-Tu, reducing its ability to interact with the factor-binding center 16s rRNA, leads to a dramatic reduction in EF-Tu GTPase activity

D. Pyrophasphatic editing is key mechanism to ensure fidelity

#Question id: 4275

#Unit 3. Fundamental Processes

CCA-adding enzymes add a specific sequence without a template because

#Question id: 4276

#Unit 3. Fundamental Processes

Which of the following post-translational modifications of proteins occur(s) in the lumen of the endoplasmic reticulum?

a. glycosylation                       b. formation of disulfide bonds

c. conformational folding and formation of quaternary structure

d. proteolytic cleavage                        e. aldol condensation of sugars

#Question id: 4277

#Unit 3. Fundamental Processes

N-linked oligosaccharides in glycoproteins

#Question id: 4278

#Unit 3. Fundamental Processes

N-terminal sequences usually function as targeting signals for protein transport into

a. the nucleus.             b. peroxisomes.                       c. chloroplasts.

d. the rough endoplasmic reticulum.   e. mitochondria.