TLS Online TPP Program

#Question id: 3828


Why does E. coli need both DNA polymerase III and DNA polymerase I?

#Unit 3. Fundamental Processes
  1. DNA polymerase III lacks the 5ʹ → 3ʹ exonuclease activity needed to remove RNA primers.

  2. Each polymerase is specific for only one strand of DNA. DNA polymerase III acts nly on the leading strand, and DNA polymerase I acts only on the lagging strand.

  3. DNA polymerase I is needed to join the Okazaki fragments.

  4. The DNA replication is bidirectional; one polymerase is used for each direction.