TLS Online TPP Program

#Question id: 24282


Which of the following statement describes outside-in signaling?

#Unit 4. Cell Communication and Cell Signaling
  1. Binding of integrins to their ligands induces conformational changes in their cytoplasmic domains, directly or indirectly altering their interactions with cytoplasmic proteins
  2. Binding of integrins to their ligands induces conformational changes in their transmembrane domains, directly or indirectly altering their interactions with cytoplasmic proteins
  3. Binding of cytoskeletal proteins intracellularly induces conformational changes in extracellular domains of integrins, so it unable to bind to the ligands
  4. intracellular signaling pathways can, via adapter proteins, modify the ability of integrins to bind to their extracellular ligands