Which of the following is correct regarding mammalian cells, Cdc6 & Cdt1

a. It is phosphorylated during S phase

b. It is degraded by the ubiquitination pathway

c. Cdt1 is initially stabilized by the protein Geminin

d. Cdt1 is initially degraded by the protein Geminin

TLS Online TPP Program

#Question id: 28699

#Unit 2. Cellular Organization

First sugar residue is attached to dolichol by ___

TLS Online TPP Program

#Question id: 28700

#Unit 2. Cellular Organization

Biosynthesis of all N-linked oligosaccharides begins in the rough ER with a preformed branched oligosaccharide precursor Glc3Man9(GlcNAc)2, Which of the following statements is incorrect about these biosynthesis?

a) the oligosaccharide precursor is assembled on a membrane- attached anchor called dolichol phosphate

b) First sugar residue is attached to dolichol by a glycosidic bonds & the other

sugars are added by high-energy pyrophosphate

c) Two N- acetylglucosamine (GlcNAc) and five mannose residues are added one at a time to a dolichol phosphate on the lumen

d) Four mannose and three glucose  residue are added one to a dolichol phosphate on the luminal side

TLS Online TPP Program

#Question id: 28701

#Unit 2. Cellular Organization

Which of the following inhibitors inhibits the synthesis of all N-linked oligosaccharides in cells?

TLS Online TPP Program

#Question id: 28702

#Unit 2. Cellular Organization

Oligosaccharyl transferase enzyme involves to transferred precursor oligosaccharide 

TLS Online TPP Program

#Question id: 28703

#Unit 2. Cellular Organization

Oligosaccharyl transferase enzyme involves to transferred precursor oligosaccharide from a dolichol lipid anchor to the tripeptide sequences, which of the following tripeptide sequences are substrates for oligosaccharyl transferase ?

TLS Online TPP Program

#Question id: 28704

#Unit 2. Cellular Organization

What is the function of Glycosidase in biosynthesis of all N-linked oligosaccharides in the ER?