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TLS Online TPP Program
#Question id: 15307
#Unit 4. Cell Communication and Cell Signaling
In attached table some Tumor‐Suppressor Genes are given with their inherited syndrome; select correctly matched genes with their causing syndrome
TLS Online TPP Program
#Question id: 15360
#Unit 4. Cell Communication and Cell Signaling
The cytochrome P450 constitute a superfamily of heme-containing enzymes that occur in nearly all living organisms, from bacteria to mammals, These monooxygenases, which in animals are embedded in the endoplasmic reticulum membrane, catalyze reactions of the sort
RH + O2 + 2 H+ + 2e− → ROH + H2O
The electrons (e−) are supplied by NADPH, which passes them to cytochrome P450’s heme prosthetic group via the intermediacy of the enzyme NADPH P450 reductase. Here RH represents a wide variety of usually lipophilic compounds for which the different cytochromes P450 are specific. They include
a. polycyclic aromatic hydrocarbons
b. polycyclic biphenyls
c. frequently carcinogenic compounds that are present in tobacco smoke, broiled meats, and other pyrolysis products
d. which were widely used in electrical insulators and as plasticizers and are also carcinogenic.
TLS Online TPP Program
#Question id: 15361
#Unit 4. Cell Communication and Cell Signaling
The chemical benzo(a)pyrene, found in cigarette smoke as well as in coal tar, undergoes metabolic activation in the lungs to form a potent mutagen that mainly, causes conversion of guanine (G) to thymine (T) bases, a transversion mutation, When applied to cultured bronchial epithelial cells, activated benzo(a)pyrene induces many mutations, including inactivating mutations of the p53 gene, at codon number______
TLS Online TPP Program
#Question id: 15362
#Unit 4. Cell Communication and Cell Signaling
Aflatoxin a fungal metabolite found in moldy grains, induces
TLS Online TPP Program
#Question id: 15363
#Unit 4. Cell Communication and Cell Signaling
Epithelial-to-mesenchymal transition (EMT) is thought to play a crucial role during the process of metastasis in some cancers, Snail and Twist are the two transcription factors, function as EXCEPT
TLS Online TPP Program
#Question id: 15364
#Unit 4. Cell Communication and Cell Signaling
In normal cells, FOS and MYC mRNAs and the proteins they encode are intrinsically unstable and degrade rapidly after the genes are transcribed, Conversion of the MYC proto-oncogene into an oncogene can occur by different mechanisms, Other members of this protein set include MAD, MAX, and MNT, choose incorrect statement regarding this,