TLS Online TPP Program

#Question id: 4091


To avoid being degraded by nuclear exonucleases, nascent transcripts, pre-mRNA-processing intermediates, and mature mRNAs in the nucleus must have their ends protected. Which of the following mechanism are present in the cell to protect mRNA from degradation?

I. The 5′ cap is protected because it is bound by a heterodimeric nuclear cap-binding complex (CBC), which protects it from 5′ exonucleases and also functions in export of the mRNA to the cytoplasm.

II. 5’-5’ phosphodiester bond in the cap of mRNA plays crucial role in protection

III. The 3′ end of a nascent transcript lies within the RNA polymerase and is thus inaccessible to exonucleases 

#Unit 3. Fundamental Processes
  1. I & II only

  2. II & III only  

  3. II only

  4. I, II & III