TLS Online TPP Program

#Question id: 4256


With respect to CpG islands in our genomic DNA, which, if any, of the following descriptions do not apply?

1) frequently occurring (there are about 30,000 in the human genome).

2) long DNA sequences (typically from 10 kb to 100 kb in length).

3) low CG dinucleotide frequency.

4) frequently associated with transcriptional start sites.

#Unit 2. Cellular Organization
  1. 1 and 3

  2. 2 only

  3. 2 and 3

  4. 3 only

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TLS Online TPP Program

#Question id: 4072

#Unit 3. Fundamental Processes

The C-terminal activation domain of transcriptional activators is capable of

a. binding to DNA. 

b. stimulating transcription.

c. interaction with other transcriptional machinery.

d. functioning in a fusion with a DNA-binding domain from an unrelated transcriptional activator.

TLS Online TPP Program

#Question id: 4073

#Unit 3. Fundamental Processes

The expression of which gene(s) is (are) regulated by promoter proximal pausing?

TLS Online TPP Program

#Question id: 4074

#Unit 3. Fundamental Processes

The promoter sequences of RNA polymerase III-transcribed genes are located

TLS Online TPP Program

#Question id: 4075

#Unit 3. Fundamental Processes

Pre-mRNA molecules

a. exist as free RNA molecules in eukaryotic cells.

b. are associated with an abundant set of nuclear proteins.

c. are mostly located in the cytoplasm.

d. are located in the nucleus.

TLS Online TPP Program

#Question id: 4076

#Unit 3. Fundamental Processes

RNA-binding proteins

a. can be identified by chromatography of UV irradiated nuclear extracts over oligo-dT columns.

b. can be identified by sequence homology to known RNA-binding domains.

c. have a conserved structure as seen by X-ray crystallographic analysis.

d. alter the secondary structure of pre-mRNAs, which decreases interactions with other RNAs or proteins.

e. always remain in the nucleus.

TLS Online TPP Program

#Question id: 4077

#Unit 3. Fundamental Processes

Which of the following is (are) associated with most polyadenylation events?

a. cleavage of the 5ยด end of the RNA molecule

b. an assembly of a large, multiprotein complex

c. the AAUAAA site upstream of where polyadenylation will occur

d. a GU-rich or U-rich region near the cleavage site

e. slow addition of A residues followed by rapid addition of 200 to 250 more A residues