Regulating iron levels in the human body is critical. Many proteins use iron as a cofactor, including the oxygen transport proteins hemoglobin and myoglobin. Consistent with the important role of iron in oxygen transport and energy production, a shortage of iron in the human body (called anemia) results in an overall feeling of weakness. On the other hand, excess iron is toxic to cells and can contribute to liver damage, heart failure, and diabetes. The iron-binding protein Ferritin is the major regulator of iron levels in the human body. Which of the following are INCORRECT regarding ferritin? A. Ferritin translation is regulated by iron-binding proteins called iron regulatory proteins B. The levels of transferrin, transferrin receptor, are also crucial to cellular iron homeostasis C. Aconitase regulates synthesis of these three proteins is regulated in response to iron availability D. apoaconitase, is actually IRE that has ability to bind to specific sequences in the mRNAs for the transferrin receptor and ferritin, thus regulating protein synthesis at the translational level. E. IRE binding to mRNA increases synthesis of ferritin many folds. -triyambak.org