TLS Online TPP Program

#Question id: 4539


The yeast S. cerevisiae exists in three forms: two haploid cells of different mating types—a and alpha and the diploid formed when an a and an a cell mate and fuse. The a cell and the a cell each encodes cell-type-specific regulators: a cells make the regulatory protein a1, and alpha cells make the proteins alpha1 and alpha2. A fourth regulatory protein, called Mcm1, is also involved in regulating the mating-type-specific genes (and many other genes) and is present in both cell types which shows Combinatorial Control.

The arrangement of regulators at the promoters of a-specific genes and a-specific genes is

cell type:

gene regulatory proteins:

target genes:

1.a cell (haploid)

a1

Mcm1

aSG

alphaSG

2.αlpha cell (haploid)

alpha 1

alpha 2

Mcm2

hSG

3.a/αlpha cell (diploid)

a1

Mcm2

alpha2

#Unit 3. Fundamental Processes
  1. 1-aSG & hsG-ON, 2-alphaSG & hSG-ON, 3-All target genes are OFF

  2. 1-aSG & hsG-OFF, 2-alphaSG & hSG-OFF, 3-All target genes are ON

  3. 1- alphaSG & hSG-ON, 2- aSG & hsG-ON, 3-All target genes are OFF

  4. 1- alphaSG & hSG-ON, 2- aSG & hsG-ON, 3-All target genes are ON