Match the Variation of Reaction Spontaneity (Sign of ΔG) given in Column I with the Signs of ΔH and ΔS given in column II.

COLUMN I	COLUMN II
	ΔH	ΔS	ΔG = ΔH – TΔS
1.	−	+	a. The reaction is both enthalpically and entropically opposed. It is nonspontaneous (endergonic) at all temperatures.
2.	−	−	b. The reaction is enthalpically opposed (endothermic) but entropically favored. It is spontaneous only at temperatures above T = ΔH/ΔS.
3.	+	+	c. The reaction is enthalpically favored but entropically opposed. It is spontaneous only at temperatures below T = ΔH/ΔS.
4.	+	−	d. The reaction is both enthalpically favored (exothermic) and entropically favored. It is spontaneous (exergonic) at all temperatures.

#Question id: 4517

#Unit 3. Fundamental Processes

Statement: When phosphorylated, CREB binds to CREs near certain genes and acts as a transcription factor, turning on the expression of these genes.

Explanation: I-Regulation can result from phosphorylation of Nuclear transcription factor

II- Activation of a protein kinase in the nucleus that phosphorylates specific DNA-binding proteins and thereby alters their ability to act as transcription factors.

#Question id: 4518

#Unit 3. Fundamental Processes

The sequence of transcriptional activation events at a typical Pol II promote

I- Mediator facilitates the binding of TBP (or TFIID) and TFIIB, and the other basal transcription factors and Pol II then bind.

II- Activators bind the DNA.

III-The activators recruit the histone modification/nucleosome remodeling complexes and a coactivator such as Media.

IV- Phosphorylation of the carboxyl-terminal domain (CTD) of Pol II leads to transcription initiation.

#Question id: 4519

#Unit 3. Fundamental Processes

Some steroid hormone receptors function in the nucleus as transcription activators, stimulating the transcription of certain genes when a particular steroid hormone signal is present. When the hormone is absent, the receptor proteins revert to a repressor conformation, preventing the formation of PICs. It is an example of;

#Question id: 4520

#Unit 3. Fundamental Processes

Interaction of two regulatory proteins is often mediated by domains containing

#Question id: 4521

#Unit 3. Fundamental Processes

Three distinct types of structural domains used in activation by transcription activators, except one

#Question id: 4522

#Unit 3. Fundamental Processes

Gal4p contains a