#Question id: 2885
#Unit 2. Cellular Organization
Which of the following function of DNA methylation in mammalian cell is incorrect?
#Question id: 2886
#Unit 2. Cellular Organization
Match the following sites of modifications on histones given in Column I with their effect on transcription given in Column II.
COLUMN I COLUMN II
1) Methylation of H3K36 in transcribed region a) Activation
2) Ubiquitinylation of H2BK120 in mammals b) Repression
3) Phosphorylation of H2AT120 c) Elongation
4) Hypoacetylated Lysine
5) Acetylation of H4K8
#Question id: 2887
#Unit 2. Cellular Organization
Which of the following reasons has led to the evolutionary selection of an extra methyl group in DNA?
#Question id: 2888
#Unit 2. Cellular Organization
Repressive complexes have been discovered that are composed of multiple repressing proteins bound to RNAs many kilobases in length that do not contain long open reading frames and are consequently called long noncoding RNAs or lncRNAs. Which of the following statements is correct regarding the regulation of these lncRNAs?
#Question id: 2889
#Unit 2. Cellular Organization
The edges of each base pair are exposed in the major and minor grooves, creating a pattern of hydrogen-bond donors and acceptors and of hydrophobic groups (allowing for Vander Waals interactions) that identifies the base pair. The edge of an C : G base pair displays the following chemical groups in the following order in the major groove:
#Question id: 2890
#Unit 2. Cellular Organization
Match individual variant histones i) to iv) to one or more of the possible functions listed in a) to g).
Variant histones Functions
i) CENP-A a) DNA replication
ii) H2A.X b) As a barrier to stop heterochromatin spreading
iii) H2A.Z c) DNA repair
iv) H3.3 d) Transcriptional activation
e) Kinetochore assembly
f) Recombination
g) Genome maintenance