#Question id: 5238

all tissue types possess a unique stem cell niche, and despite many differences among the niche architecture of different tissues, several common principles of stem cell regulation can be applied to all environments. These principles involve extracellular mechanisms leading to intracellular changes that regulate stem cell behavior.

Column A	Column B
I. Extracellular regulatory mechanisms	i. Regulation by endocrine, paracrine, or juxtacrine mechanisms
II. Intracellular regulatory mechanisms	ii. Regulation by a network of transcription factors
	iii. Epigenetic regulation
	iv. Regulation by cell-to-cell and cell-to-matrix adhesions
	v. Regulation by cytoplasmic determinants

Match the following regulatory mechanism (column A) with the factors that regulate stem cell behavior (column B).