The somatic cells of the hub create asymmetric proliferation by secreting a  factor which involve onto the cells attached to them, these factors are___

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#Question id: 15189

#Unit 4. Cell Communication and Cell Signaling

Which of the following  cells control the differentiation of HSCs (hematopoietic stem cells )?

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#Question id: 15303

#Unit 4. Cell Communication and Cell Signaling

Neurofibromatosis, a benign tumor of the sheath cells that surround nerves, is caused by

a.  Loss of both alleles of NF1

b.  Mutation in RAS GAP-type protein

c.  A single mutant NF1 allele

d.  Mutation in SRC protein

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#Question id: 15304

#Unit 4. Cell Communication and Cell Signaling

An activating mutation of one of the two alleles of a proto-oncogene converts it into an oncogene, This can occur by EXCEPT

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#Question id: 15305

#Unit 4. Cell Communication and Cell Signaling

The multi-hit model, which proposes that multiple mutations are needed to cause cancer, which of the following is incorrect regarding to this model?

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#Question id: 15306

#Unit 4. Cell Communication and Cell Signaling

The transformation of a normal cell to a cancer cell is accompanied  by the loss of function of one or more tumor‐suppressor genes. High‐throughput sequencing studies have identified hundreds of genes that are implicated as tumor suppressors in humans. Some of the better characterized genes;

Gene	Primary tumor	Proposed function
i) APC	Colorectal	Binds β-catenin acting as transcription factor
ii) BRCA1	Breast	DNA repair
iii) MSH2, MLH1	Melanoma, pancreatic	p16: Cdk inhibitor ARF: stabilizes p53
iv) E-Cadherin	Breast, colon	Cell adhesion molecule
v) INK4a	Colorectal	Mismatch repair
vi) NF1	Neurofibromas	Activates GTPase of Ras

Choose incorrect matching regarding tumor‐suppressor genes/primary tumor/proposed functions;

TLS Online TPP Program

#Question id: 15307

#Unit 4. Cell Communication and Cell Signaling

In attached table some Tumor‐Suppressor Genes are given with their inherited syndrome; select correctly matched genes with their causing syndrome

Gene	Inherited syndrome
i. TP53	Li-Fraumeni syndrome
ii. INK4a	Familial melanoma
iii. PTEN	Familial gastric cancer
iv. E-Cadherin	Cowden disease
v. VHL	von Hippel-Lindau syndrome