What will cause the phosphorylation of T14 and Y15 in this G-loop?

a) It introduces negative charge that electrostatically interferes with the binding of ATP in the catalytic pocket

b) It introduces ionic bond interferes with the binding of ATP in the catalytic pocket

c) play a critical role in controlling CDK activity

d) Allows the binding of CDK with cyclins

Which of the following is correct about phosphorylation;

TLS Online TPP Program

#Question id: 33360

#Unit 1. Structure and Function of Biomolecules

a. HbS (sickle-cell Hb): substitutes a Val for a Glu on the surface

b. Hb Cowtown: eliminates an ion pair involved in T-state stabilization

c. Hb Memphis: substitutes one uncharged polar residue for another of similar size on the surface

d. Hb Bibba: substitutes a Pro for a Leu involved in an α helix

Which Hb variant least likely to cause pathological symptoms

TLS Online TPP Program

#Question id: 33361

#Unit 1. Structure and Function of Biomolecules

a. Hb Cowtown: eliminates an ion pair involved in T-state stabilization

b. Hb Milwaukee: substitutes a Glu for a Val

c. Hb Providence: substitutes an Asn for a Lys that normally projects into the central cavity of the tetramer

d. Hb Philly: substitutes a Phe for a Tyr,

Which Hb variant will not bind to BPG

TLS Online TPP Program

#Question id: 33362

#Unit 1. Structure and Function of Biomolecules

a. Hb Cowtown: eliminates an ion pair involved in T-state stabilization

b. Hb Milwaukee: substitutes a Glu for a Val

c. Hb Providence: substitutes an Asn for a Lys that normally projects into the central cavity of the tetramer

d. Hb Philly: substitutes a Phe for a Tyr

Which Hb variant will have changed pI as compared to HbA

TLS Online TPP Program

#Question id: 33363

#Unit 1. Structure and Function of Biomolecules

An antibody binds to an antigen with a Kd of 5 X10^-8 M. At what concentration of antigen will θ be 0.2

TLS Online TPP Program

#Question id: 33364

#Unit 1. Structure and Function of Biomolecules

An antibody binds to an antigen with a Kd of 5 X10^-8 M. At what concentration of antigen will θ be 0.5

TLS Online TPP Program

#Question id: 33365

#Unit 1. Structure and Function of Biomolecules

An antibody binds to an antigen with a Kd of 5 X10^-8 M. At what concentration of antigen will θ be 0.6