Biosynthesis of all N-linked oligosaccharides begins in the rough ER with a preformed branched oligosaccharide precursor Glc3Man9(GlcNAc)2, Which of the following statements is incorrect about these biosynthesis?

a) the oligosaccharide precursor is assembled on a membrane- attached anchor called dolichol phosphate

b) First sugar residue is attached to dolichol by a glycosidic bonds & the other

sugars are added by high-energy pyrophosphate

c) Two N- acetylglucosamine (GlcNAc) and five mannose residues are added one at a time to a dolichol phosphate on the lumen

d) Four mannose and three glucose  residue are added one to a dolichol phosphate on the luminal side

#Question id: 848

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the brain diseases is not caused by the misfolding of brain proteins in mammals

#Question id: 849

#Unit 1. Molecules and their Interaction Relevant to Biology

The rigidity of the peptide unit and the restricted set of allowed phi and psi angles limits the number of structures accessible to the unfolded form sufficiently to allow:-

#Question id: 850

#Unit 1. Molecules and their Interaction Relevant to Biology

The experimental inverse of protein structure prediction, has provided insights into protein folding and stability. Protein design attempts to construct an amino acid sequence that will form a structure such as a sandwich of β sheets or a bundle of α helices;

#Question id: 851

#Unit 1. Molecules and their Interaction Relevant to Biology

Methods is the Rosetta program, formulated by David Baker. To satisfy the program’s computational needs, a volunteer network of ∼100,000 computers, known as Rosetta@home, provides the 500,000 or so hours of processing time required to generate a structure;

#Question id: 852

#Unit 1. Molecules and their Interaction Relevant to Biology

.________ enzyme revealed the relation between the amino acid sequence of a protein and its conformation.

#Question id: 853

#Unit 1. Molecules and their Interaction Relevant to Biology

In the presence of a large excess of _______ the disulfides (cystines) are fully converted into sulfhydryls (cysteines).