Most common CFTR mutation is a ΔF508 causes_

a)Changing the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec24

b)Changing the conformation of the cytosolic portion of CFTR so that the signal is unable to bind to Sec23

c)blocking its packaging into COPII vesicles budding from the ER

d)blocking its packaging into COPI vesicles budding from the ER

Which of the following is correct result of mutated CFTR?

#Question id: 1402

#Unit 4. Cell Communication and Cell Signaling

Which of the following oncoproteins possess(es) protein kinase activity?

#Question id: 1403

#Unit 4. Cell Communication and Cell Signaling

Tumor-suppressor genes encode proteins with which of the following functions?

a. growth-promoting               b. growth-arresting                  c. pro-apoptotic

d. anti-apoptotic                      e. DNA repair

#Question id: 1404

#Unit 4. Cell Communication and Cell Signaling

Which of the following are transcription factors?

#Question id: 1405

#Unit 4. Cell Communication and Cell Signaling

A gain-of-function mutation in which of the following would have the same effect as a gain-of-function mutation in Ras?

#Question id: 1406

#Unit 4. Cell Communication and Cell Signaling

Which of the following is a consequence of p53 stabilization?

a. stabilization of Cdc25A      b. activation of ATM                c. blocked apoptosis

d. transcription of p21                        e. DNA repair

#Question id: 1407

#Unit 4. Cell Communication and Cell Signaling

Which of the following is pro-apoptotic?

a. Bax              b. Bcl-2                       c. p53              d. protein kinase B      e. PTEN