Practice Questions

TLS Online TPP Program

#Question id: 5654

Two human disorders, Prader-Willi syndrome and Angelman syndrome, occur when a small deletion in a specific region of chromosome 15 is contributed by either the father or mother, respectively. Why does this small deletion not behave as a recessive allele for either syndrome, that is, why is its loss not made up for by the good copy of the region on chromosome 15 contributed by the other parent?

#Unit 5. Developmental Biology

This portion of chromosome 15 is invariably mutated, so the other parent contributes recessive alleles that are thus homozygous and perturb development.
The copy of chromosome 15 from the other parent has genes in the region of the deletion that are imprinted, and thus inactive; in the absence of any active copies of these genes, development cannot proceed normally.
The genes in this portion of chromosome 15 are special in that they are required in two copies for normal development, and so the loss of one set does not allow normal development.
Chromosomes with deletions do not go through mitosis correctly, so cell divisions in the embryo result in cells with abnormal numbers of chromosomes, and these cells do not contribute properly to the development of the organism.

More Questions

TLS Online TPP Program

#Question id: 27412

#Unit 1. Molecules and their Interaction Relevant to Biology

Choose the correct

1. Mutation in B-galactosidase leads to the deposition of GM1 causes Generalized gangliosidosis

2. Mutation in hexosaminidase leads to the deposition of GM2 causes Tay-Sachs

3. Mutation in glucocerebrosidase leads to the deposition of Glc causes Gaucher disease

4. Mutation in sphingomyelinase leads to the deposition of Phosphocholine causes Niemann-Pick disease

TLS Online TPP Program

#Question id: 27413

#Unit 1. Molecules and their Interaction Relevant to Biology

Sandhoff disease are related to the mutation in which of the following enzyme

TLS Online TPP Program

#Question id: 27414

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is correctly describing the common structure of any sterol

TLS Online TPP Program

#Question id: 27415

#Unit 1. Molecules and their Interaction Relevant to Biology

Lipid aggregation are catalyzed by which of the following bond effect

TLS Online TPP Program

#Question id: 27416

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following statement is true

1. Wedge or cone shape lipid promote the formation of monolayer micelle

2. Wedge or cone shape lipid promote the formation of lipid bilayer

3. Cylindrical shaped lipid majorly promote the formation of perfect lipid bilayer region

4. Cylindrical shaped lipid majorly promote the formation of monolayer micelle

TLS Online TPP Program

#Question id: 27417

#Unit 1. Molecules and their Interaction Relevant to Biology

Which of the following is correct composition of mammalian or eukaryotic plasma membrane

Note = OML = outer mono layer, IML = inner mono layer