#Question id: 1384
#Unit 4. Cell Communication and Cell Signaling
Mutations that block expression of the E-cadherin gene are thought to be an important step in metastasis. To better understand how loss of E-cadherin contributes to metastasis, scientists created two cell lines that differed in their expression of E-cadherin. One cell line expressed normal E-cadherin, but at 10% of the usual levels. The other cell line expressed normal E-cadherin at the usual levels, and also, at high levels a mutant form that included the cytoplasmic domain but lacked the rest of the protein. Both cell lines exhibited strongly reduced cell adhesion in culture. However, only the cell line with reduced expression of normal E-cadherin metastasized when introduced into mice.
Which of the following hypotheses is most consistent with the observations on cell adhesion and metastasis in these cell lines?
#Question id: 19562
#Unit 12. Applied Biology
#Question id: 33282
#Unit 2. Cellular Organization
#Question id: 15458
#Unit 2. Cellular Organization
#Question id: 3672
#Unit 3. Fundamental Processes
During initiation of replication