Given some statements about Hedgehog processing and secretion;

a) autoproteolytic activity that cleaves off the C-terminus to reveal a signal sequence that marks the protein for secretion 

b) autoproteolytic activity that cleaves off the N-terminus to reveal a signal sequence that marks the protein for secretion 

c) Secretion requires the addition of cholesterol and palmitic acid

d) Secretion requires the  modification of Hh by Glycosylation

Which of the following is correct prediction about processing and secretion of Hh?

#Question id: 3828

#Unit 3. Fundamental Processes

Why does E. coli need both DNA polymerase III and DNA polymerase I?

#Question id: 3829

#Unit 3. Fundamental Processes

Why is only one copy of DNA made per cell division cycle in eukaryotes despite the presence of multiple origins of replication?

#Question id: 3830

#Unit 3. Fundamental Processes

Why is DNA damage in skin cells from exposure to excessive UV light not completely reversed by photoreactivation?

#Question id: 3831

#Unit 3. Fundamental Processes

State whether the following statements is true/false regarding DNA replication.

1. In E. coli replication begins at the origin of replication and proceeds in one direction until the entire circular DNA molecule has been copied.

2. The chromosome of the fruit fly (D. melanogaster) is about twice as large as the E. coli chromosome.

3. Prokaryotic DNA replication occurs in two steps. First, ATP provides a phosphate to the growing DNA chain. This is followed by addition of a nucleoside.

4. DNA polymerase III is the largest DNA polymerase in E. coli.

5. The β subunits of E. coli DNA polymerase form a sliding clamp that surrounds the DNA strands at the replication fork.

#Question id: 3832

#Unit 3. Fundamental Processes

You briefly expose bacteria undergoing DNA replication to radioactively labeled nucleotides. When you centrifuge the DNA isolated from the bacteria, the DNA separates into two classes. One class of labeled DNA includes very large molecules (thousands or even millions of nucleotides long), and the other includes short stretches of DNA (several hundred to a few thousand nucleotides in length). Which two classes of DNA do these different samples represent?

#Question id: 3833

#Unit 3. Fundamental Processes

Regarding DNA replication, which, if any, of the following statements is incorrect?