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TLS Online TPP Program

#Question id: 5670

Embryonic stem cells can be induced in the laboratory to differentiate into muscle, nerve, pancreatic, and other specialized cell types. It has recently become possible to trigger the dedifferentiation of somatic cells back into pluripotent cells (so-called induced pluripotent stem cells or iPS cells) by artificially enhancing the production of a relatively small number of key transcriptional factors known to be required for maintenance of pluripotency. Examples of such transcription factors are OCT4 and NANOG. The production of OCT4 and NANOG (and other key regulatory proteins) is stimulated by a transcription factor known as FOXP1, a member of the Forkhead family of DNA-binding proteins. There are two isoforms of FOXP1.

Which of the following statement regarding to FOXP1 is incorrect?

#Unit 5. Developmental Biology

  1. The protein encoded by the exon 18b–carrying mRNA is called FOXP1-ES: this activates genes (OCT4, NANOG, etc.) that promote dedifferentiation, and thus stimulates iPS cell formation.

  2. In the exon 18a–containing form encodes FOXP1 itself, and this has the opposite effect: it fails to stimulate expression of OCT4 and NANOG and instead actives genes that promote differentiation.

  3. FOXP1 binds to DNA via a domain known as a Winged helix, which recognizes a particular DNA sequence.

  4. The switch from exon 18a to exon 18b substitutes 3 residues in the Winged helix region of the protein including six amino acids that are known to contact DNA.

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TLS Online TPP Program

#Question id: 7474

#General Aptitude

At what time between 2 to 3 o’ clock minute and hour hand will right angle ?
TLS Online TPP Program

#Question id: 4383

#Unit 3. Fundamental Processes

The mediator complex
TLS Online TPP Program

#Question id: 10253

#Unit 6. System Physiology – Plant

Two pathways for the splitting of sucrose are known in plants, both of which take part in the use of sucrose from phloem unloading;
TLS Online TPP Program

#Question id: 876

#Unit 1. Molecules and their Interaction Relevant to Biology

Prion protein is a normal constituent of brain tissue in all mammals which of the following statements are correct regarding prion protein

a) Strains of mice lacking the gene for PrP suffer no obvious ill effect

b) Illness occurs only when the normal cellular PRP or prpc occurs in an altered confirmation called PrPsc

c) The interaction of prpsc with the prpc converts the letter to prpsc initiating a Domino effect in which more and more the brain proteins converted to the disease causing form

d) the structure of prpsc is very different with much of the structure converted to amyloid like Alpha sheet.
TLS Online TPP Program

#Question id: 4708

#Unit 11. Evolution and Behavior

The following questions refer to the figure below, which shows an outcrop of sedimentary rock whose strata are labeled A-D. If x indicates the fossils of two closely related species, neither of which is extinct, then their remains may be found in how many of these strata?