TLS Online TPP Program

#Question id: 29098


A family in which club foot was inherited as an autosomal dominant trait. They discovered a mutation in the PITXI gene that caused club foot in this family. Through DNA testing, they determined that 11 people in the family carried the PITXI mutation, but only 8 of these people had club foot. Which of the following is the correct interpretation of the observation?

#Unit 8. Inheritance Biology
  1. The expressivity of polydactyly is 72%
  2. The penetrance of polydactyly is estimated to be 72%
  3. The polydactyly trait is showing incomplete penetrance with variable expressivity
  4. This is an example of variable expressivity